Familial thyroxine-binding globulin deficiency.

Familial thyroxine-binding globulin deficiency: search for linkage with Xg blood groups.

Radioelectrophoresis for determination of thyroid hormone binding abnormalities in human serum.

This paper describes a rapid and accurate method for determining binding abilities of thyroid hormones to their corresponding serum proteins: prealbumin, albumin and thyroxine binding globulin. A tube cell agarose gel electrophoresis is used with radioactive labelled triiodothyronine or thyroxine. The distribution curve shows characteristic peaks for prealbumin, albumin and thyroxine binding gl...

Primary thyroid failure with concomitant thyroxine binding globulin deficiency.

Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation.

A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodothyronine concentrations were normal. ...

Congenital hypothyroidism with hereditary, raised thyroxine binding globulin.

A boy with congenital hypothyroidism and hereditary raised thyroxine binding globulin is described. This hitherto unreported combination resulted in under treatment of the thyroid deficiency until serum thyroid stimulating hormone measurement became routinely available. Inadequate L-thyroxine replacement treatment between 2 and 7 years of age caused retarded bone maturation, poor growth velocit...